Hydrocodone is also used to treat as an opioid pain reliever and is considered a semi-synthetic opioid drug. Codeine is a natural opioid drug derived from morphine that reduces the anxiety and stress caused by pain.Hydrocodone and codeine both work as painkillers by changing how the brain perceives pain and these drugs work to reduce pain signals. The benefit of Codeine and Hydrocodo... https://secondnewlife.com/codeine-vs-hydrocodone/