Transcriptional deregulation caused by epigenetic or genetic alterations is a major cause of leukemic transformation. The Spi1/PU. 1 transcription factor is a key regulator of many steps of hematopoiesis. and limits self-renewal of hematopoietic stem cells. https://www.roneverhart.com/Short-Porch-Mortar-USSSA-Pro-M-12-Slowpitch-Softballs/