Purpose: The aims of this study were to establish a joint population pharmacokinetic model for voriconazole and its N-oxide metabolite in immunocompromised patients. to determine the extent to which the CYP2C19 genetic polymorphisms influenced the pharmacokinetic parameters. and to evaluate and optimize the dosing regimens using a simulating approach. Methods: A population pharmacokin... https://parisnaturalfoodes.shop/product-category/english-breakfast/